| 摘要 |
The invention concerns polypeptides of the general formula (I) :A-(Xaa)<SUB>n</SUB>-Lys-X-Lys-B wherein: i) A is -NH2, NH3+, or NH-D (D is an acyl group being biotin or an alkyl chain (C2- C22)), H)B is H, O<SUP>-</SUP> OR<SUP>1</SUP> or NR<SUP>2</SUP>R<SUP>3</SUP> and R<SUP>1</SUP>, R<SUP>2</SUP> and R<SUP>3</SUP> independently either: H or an alkyl chain (C1-C24), iii) (Xaa)<SUB>n</SUB> is an amino acid chain including any amino acid natural or not, excluding arginine and lysine, iv) "n" is between 0 - 3, and v) X is either a chain of two any amino acids (XaalXaa2), which may be the same or different, excluding arginine, lysine and excluding XaalXaa2 = Thr-Thr, Gly-His and Glu-His, or X is a spacer selected among beta-alanyl, 5- amino-valeroyl, 4-amino-cyclohexanoyl, 4-amino-butyroyl, 6-amino-caproyl and derivatives thereof. More particularly, the invention concerns polypeptides of formula (I) wherein "n" is 0 and with the formula: A -Lys-X-Lys-B; A, X and B being defined herein. Compositions containing at least one of said polypeptides and their use. |
