Compounds for control of appetite

摘要

This invention relates generally to neuropeptide Y ("NPY") Y₄ receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof, to pharmaceutical compositions containing such Y₄ receptor agonists, and to methods for treatment of mammals using the same. The NPY Y₄ receptor agonists may be administered to mammals either alone or in combination with NPY Y₂ receptor agonists including peptide YY (PYY) (3-36), analogs thereof, and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof, such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.