BINDING POLYPEPTIDES AND USES THEREOF

摘要

The invention provides antibodies or antigen binding fragments thereof to DR5
and HER-2. The antibodies and/ or antigen binding fragments thereof comprise
variant CDRs comprising highly restricted amino acid sequence diversity. The
invention also provides these polypeptides as fusion polypeptides to
heterologous polypeptides such as at least a portion of phage or viral coat
proteins, tags and linkers. In addition, compositions and methods of use for
treatment of cancer and immune related conditions are provided.