| 摘要 |
The present invention provides formulations and methods for the stabilizatio n of antibodies. In one embodiment, the invention provides the stabile formulation of antibodies that are prone to non-enzymatic fragmentation at t he hinge region. In a further embodiment, the invention provides methods of stabilization of antibodies comprising lyophilizing an aqueous formulation o f an antibody. The formulations can be lyophilized to stabilize the antibodies during processing and storage, and then the formulations can be reconstitute d for pharmaceutical administration. In one embodiment, the present invention provides methods of stabilization of anti- VEGFR antibodies comprising lyophilizing an aqueous formulation of an anti-VEGFR antibody. The formulations can be lyophilized to stabilize the ahti-VEGFR antibodies durin g processing and storage, and then the formulations can be reconstituted for pharmaceutical administration.
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