Culture conditions and growth factors affecting fate determination, self-renewal and expansion of rat spermatogonial stem cells

摘要

The present invention relates to methods of identifying and enriching rat spermatogonioal stem cells, and compositions thereof. Further, the invention relates to methods and compositions for the isolation, maintenance and proliferation of rat spermatogonial stem cells, as well as methods and compositions for the identification and use of factors influencing rat spermatogonial stem cell maintenance and proliferation.