Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents

摘要

A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR¹⁷, where R¹⁷ is hydrogen or lower alkyl; A and Y are CH, N, NR¹⁷, O, or S; C¹ and C² are each C or N, wherein C¹ and C² are the same or different; D¹ and D² are each C or N, wherein D¹ and D² are the same or different; B and Z are CH, N, or NR¹⁷, provided that B, Z, or both B and Z are not present when A, Y, or both A and Y are O, S, or NR¹⁷; R¹³, R¹⁴, R¹ and R⁸ can be present or absent, and when present are selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R¹⁵ and Rare selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R³ and R⁶ are each independently selected from the group consisting of H, hydroxy, lower alkyl, cycloalkyl, aryl, aralkyl, alkoxyl, hydroxycycloalkyl, alkoxycycloalkyl, hydroxyalkyl, aminoalkyl, acyloxy, acetoxy, and alkylaminoalkyl; and R², R⁴, R⁵ and R⁷ are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl, or R² and R⁴ together or R⁵ and R⁷ together represent a C₂ to C₁₀ alkyl, hydroxyalkyl, or alkylene, or R³ and R⁴ together or R⁶ and R⁷ together are: wherein n is a number from 1 to 3, and R⁹ is H or -CONHR¹⁰NR¹¹R¹², wherein R¹⁰ is lower alkyl and R¹¹ and R¹² are each independently selected from the group consisting of H and lower alkyl.