发明名称 |
METHODS OF DIAGNOSIS AND TREATMENT OF M. TUBERCULOSIS INFECTION AND REAGENTS THEREFOR V |
摘要 |
<p>The present invention provides isolated M. tuberculosis ribosomal protein S9 (SEQ ID NO: 1) and immunogenic peptide fragments thereof (any one of SEQ ID NOs: 2-7), and antibodies produced against the full-length protein and immunogenic peptide fragments for the diagnosis of M. tuberculosis infection in humans, for example using an antigen-based sandwich ELISA format. The present invention also provides multi-analyte assays in which the S9-based diagnostic assays of the present invention are multiplexed with the detection of immunogenic epitopes from other proteins from M. tuberculosis e.g., epitopes of the BSX protein (any one of SEQ ID NOs: 8-18) and/or glutamine synthetase protein (any one of SEQ ID NOs: 19-22) and/or the detection of antibodies against one or more other M. tuberculosis proteins in humans, uincluding antibodies against BSX and/or glutamine synthetase.</p> |
申请公布号 |
WO2007087679(A1) |
申请公布日期 |
2007.08.09 |
申请号 |
WO2007AU00093 |
申请日期 |
2007.01.31 |
申请人 |
PROTEOME SYSTEMS INTELLECTUAL PROPERTY PTY LTD;SLOANE, ANDREW;PEDERSEN, SUSANNE;COLE, ROBERT |
发明人 |
SLOANE, ANDREW;PEDERSEN, SUSANNE;COLE, ROBERT |
分类号 |
C07K14/35;A61K39/40;C07K7/08;C07K16/12;C07K17/14 |
主分类号 |
C07K14/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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