| 摘要 |
1,167,392. Tranquillisers. A. H. ROBINS CO. Inc. 13 June, 1967 [13 June, 1966], No. 27291/67. Heading A5B. [Also in Division C2] Oxazolidinones of general formulaI wherein B is -CHR"-CHR"'- or -CHR" -CHR"-CH 2 -; R is hydrogen C 1-8 alkyl, cycloalkyl, phenylalkyl or substituted phenylalkyl, the substituents being selected from halo, C 1-8 alkyl, C 1-8 alkoxy, trifluoromethyl, C 1-8 alkylmercapto, di-(C 1-8 -alkyl)amino, nitro and hydroxy; R' and R" are hydrogen or methyl; - (Nu) is a heterocyclic ring radical selected from 2, 3- or 3, 4-dehydropyrrolidinyl or 2, 3- or 3, 4-dehydropiperidinyl; and A is phenyl or substituted phenyl attached to a carbon atom of the hetero ring double bond at the 3 or 4 position, remaining valencies of the carbon atoms of said ring being satisfied by hydrogen atoms and 0-4 methyl groups, wherein phenyl substituents are selected from the list given for the substituted phenyl alkyl radical above; and acid addition salts thereof are active as major tranquillisers. They may be administered orally or parenterally in compositions containing the active ingredient together with diluents and/or carriers, whilst further active ingredients may be added e.g. sedatives, analgesics, antacids, other tranquillisers and anti appetite and antiulcer drugs.
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