Hydroxyapaltite calcium phosphate granules, method for preparing same and uses thereof

摘要

The invention concerns calcium phosphates in granular form having an X-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it consists in processing a brushite dicalcium phosphate suspension having a certain particle size distribution, using a basic solution, maintaining the pH at not less than 7.0, for a sufficient time interval to enable transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.