| 摘要 |
A topical composition comprising the extract of Ardisia crenata showing anti-inflammatory and anti-irritation effects is provided to inhibit side effects caused by essential ingredients of cosmetics including inflammation and skin irritation by inhibiting iNOS(inducible nitric oxide synthase) activity, expression of iNOS and COX-2(cyclooxygenase-2) genes, and production of PGE2(prosta-glandin E2), IL-6(interleukin 6) and IL-8. The topical composition comprises 0.001-90 wt.%, preferably 0.01-10 wt.% of the extract of Ardisia crenata showing anti-inflammatory and anti-irritation effects which is prepared by extracting Ardisia crenata with at least one solvent selected from water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, butyleneglycol, propyleneglycol, hydrous butyleneglycol, hydrous propyleneglycol and hydrous glycerin at 50-100 deg.C for 2-5 hours, wherein the composition is a pharmaceutical composition formulated as cream, gel, patch, spray, ointment, lotion, liniment, pasta or cataplasma or a cosmetic composition formulated as skin lotion, nutrition lotion, nutrition cream, massage cream, essence or pack. A daily dosage of the composition is 0.0001-100 mg/kg, preferably 0.001-10 mg/kg.
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