2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES

摘要

This invention concerns the use of a compound of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is hydrogen, halo, C_1-6alkyl, Het¹, HO-C_1-6alkyl-, cyano-C_1-6alkyl-, amino-C(=O)-C_1-6alkyl-, formylamino-C_1-6alkyl-, C_1-6alkyl-C(=O)-NH-C_1-6alkyl-, mono- or di(C_1-6alkyl)amino-C(=O)-C_1-6alkyl-, phenyl-C_1-6alkyl-, or He⁴-C_1-6alkyl-; Q is phenyl, pyridyl, benzofuranyl, 2,3-dihydro-benzofuranyl, pyrazolyl, isoxazolyl or indazolyl wherein each of said ring systems is optionally being substituted with up to three substituents each independently selected from halo, cyano, C_1-6alkyl, C_1-6alkyl -O-, C_1-6alkyl, Ar or polyhaloC_1-6alkyl; L is phenyl, pyridyl, pyrimidazolyl, 8-Azapyrimidazolyl, pyridazinyl, imidazothiazolyl or furanyl wherein each of said ring systems may optionally be substituted with one or two or more substituents, each substituent independently being selected from halo, hydroxy, amino, cyano, C_1-6alkyl or C_1-6alkyl-O-; Het¹ represents morpholinyl; pyrazolyl or imidazolyl; Het⁴ represents morpholinyl, pyrazolyl or imidazolyl; Ar represents phenyl optionally substituted with halo, C_1-6alkyl, C_1-6alkyl-O- or polyhaloC_1-6alkyl; for the manufacture of a medicament for the prevention or the treatment or prophylaxis of psychotic disorders, intellectual impairment disorders or diseases or conditions in which modulation of the a7 nicotinic receptor is beneficial.