| 摘要 |
This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder. |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK;ROSEN, MICHAEL, R.;BRINK, PETER, R.;ROBINSON, RICHARD, B.;GIROUARD, STEVEN, D.;KENKNIGHT, BRUCE, H.;COHEN, IRA, S. |
发明人 |
ROSEN, MICHAEL, R.;BRINK, PETER, R.;ROBINSON, RICHARD, B.;GIROUARD, STEVEN, D.;KENKNIGHT, BRUCE, H.;COHEN, IRA, S. |
