发明名称 |
METHODS TO TREAT DISEASE STATES BY INFLUENCING THE SIGNALING OF OX40-RECEPTORS AND HIGH THROUGHPUT SCREENING METHODS FOR IDENTIFYING SUBSTANCES THEREFOR |
摘要 |
<p>OX40L inhibits the generation of IL-10-producing Tr1 cells from naïve and memory CD4+ T cells induced by the immunosuppressive drugs dexamethasone and vitamin D3. This unique function of OX40L is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. OX40L also strongly inhibits the generation of IL-10-producing Tr1 cells induced by two physiological stimuli provided by inducible costimulatory ligand and immature DCs and inhibits the production of IL-10 by regulatory T cells. It has thus been shown that signaling the OX40-receptor on human T cells by monoclonal antibodies, small molecules, or OX40L regulates the generation and function of IL-10 producing immunosuppressive T cells. Also provided are high throughput methods for identifying substances that promote or inhibit the generation and function of IL-10 producing T cells. Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX40L.</p> |
申请公布号 |
WO2007084559(A2) |
申请公布日期 |
2007.07.26 |
申请号 |
WO2007US01228 |
申请日期 |
2007.01.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;LIU, YONG-JUN;ITO, TOMOKI |
发明人 |
LIU, YONG-JUN;ITO, TOMOKI |
分类号 |
A61K38/19 |
主分类号 |
A61K38/19 |
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