OLIGO DOUBLE-STRANDED RNA AND MEDICINAL COMPOSITION

摘要

It is intended to provide an double-stranded RNA oligonucleotide inhibiting the replication of HCV and a medicinal composition containing this double-stranded RNA oligonucleotide for treating and/or preventing a disease induced by infection with HCV. The present invention relates to a double-stranded RNA oligonucleotide inhibiting the replication of HCV which is characterized by having a double-stranded portion comprising a pair of RNAs, SEQ ID NO.3 and SEQ ID NO.4 without the two deoxythymidine monophosphate (hereinafter referred to as "dT") nucleotides of at the respective 3'-termini, or a pair of RNAs, SEQ ID NO.2 and SEQ ID NO.5, without the two dT nucleotides at the respective 3'-terminals; and a medicinal composition containing this double-stranded RNA oligonucleotide together with a suitable carrier.