发明名称 |
Complex of hepatitis B virus-specific antigenic peptides associated with heat shock proteins and the application thereof |
摘要 |
The present invention provides a kind of HBV-antigen bound to heat shock proteins (hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma.
|
申请公布号 |
US7247712(B2) |
申请公布日期 |
2007.07.24 |
申请号 |
US20030344502 |
申请日期 |
2003.07.28 |
申请人 |
INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES |
发明人 |
TIAN BO;MENG SONGDONG;GAO GEORGE F. |
分类号 |
A61K38/10;A61K39/29;A61P1/16;A61P31/20;A61P35/00;C07K14/02;C07K14/47;C07K19/00 |
主分类号 |
A61K38/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|