MANNHEIMIA HAEMOLYTICA CHIMERIC OUTER MEMBRANE PROTEIN PLPE AND LEUKOTOXIN EPITOPES AS A VACCINE OR VACCINE COMPONENT AGAINST SHIPPING FEVER

摘要

Vaccine preparations for the prevention and treatment of bovine respiratory disease (BRD) and, in particular, its most severe form, termed "shipping fever", are provided. The preparations comprise chimeric proteins comprising immunodominant epitopes of recombinant Mannheimia haemolytica outer membrane protein PIpE, and immunodominant epitop s of recombinant M. haemolytica leukotoxin.