发明名称 |
C-2'-METHYLIERTE PACLITAXEL-DERIVATE ZUR VERWENDUNG ALS ANTITUMORALE MITTEL |
摘要 |
Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R<SUP>1 </SUP>is t-butoxycarbonyl or benzoyl; R<SUB>2 </SUB>is hydroxy; R<SUB>3 </SUB>is hydrogen or, together with R<SUB>2</SUB>, it forms the residue of a cyclic carbonate of formula: II with the proviso that when R3 is hydrogen, R is different from phenyl. Compounds of formula (I) have antitumor activity |
申请公布号 |
DE60220524(D1) |
申请公布日期 |
2007.07.19 |
申请号 |
DE2002620524 |
申请日期 |
2002.07.23 |
申请人 |
INDENA S.P.A. |
发明人 |
BOMBARDELLI, EZIO;FONTANA, GABRIELE;BATTAGLIA, ARTURO;CIMITAN, SAMANTA |
分类号 |
A61K31/337;A61P35/00;C07D305/14;C07D407/12;C07D409/12 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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