发明名称 |
WÄSSRIGE DISPERSION STABILER NANOPARTIKEL EINES WASSERUNLÖSLICHEN WIRKSTOFFS UND EIN HILFSSTOFF WIE MITTELKETTIGE TRIGLYCERIDE (MCT) |
摘要 |
A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening. |
申请公布号 |
AT365537(T) |
申请公布日期 |
2007.07.15 |
申请号 |
AT20020745697T |
申请日期 |
2002.08.01 |
申请人 |
ASTRAZENECA AB |
发明人 |
SKANTZE, PIA;SKANTZE, TOMMY;VON CORSWANT, LARS;ZZACKRISSON SCHANTZ, ANNA;LINDFORS, PER;OLSSON, ULF |
分类号 |
A61K9/10;A61K9/16;A61K9/51;A61K47/10;A61K47/14;A61K47/44 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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