发明名称 |
ASYMMETRIC REDUCTION METHOD |
摘要 |
<p>Disclosed is a novel method for producing (2S)-2-benzyl-3-(cis- hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. Specifically disclosed is a method for producing (2S)-2-benzyl-3-(cis- hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2- isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the general formula (I) below and a rhodium compound. [Chemical formula 4] (I) (In the formula, R<SUP>1</SUP> represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R<SUP>2</SUP> and R<SUP>3</SUP> independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration.)</p> |
申请公布号 |
WO2007077818(A1) |
申请公布日期 |
2007.07.12 |
申请号 |
WO2006JP325875 |
申请日期 |
2006.12.26 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD.;MATSUMOTO, YOSHINORI;TAKEUCHI, YUKI;YAMAMOTO, HIROYUKI |
发明人 |
MATSUMOTO, YOSHINORI;TAKEUCHI, YUKI;YAMAMOTO, HIROYUKI |
分类号 |
C07B53/00;C07D209/44;A61K31/4035;A61P3/10;C07B61/00 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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