发明名称 |
LAMININ RECEPTOR TARGETING METHOD FOR DELIVERING A TOXIC AGENT INSIDE A CELL |
摘要 |
The present invention is based, at least in part, on the discovery that laminin binding protein p67 (LBP/p67) is internalized, and thus able to deliver toxic agents into cells, e.g. t cancer cells which express LBP/p67, to thereby induce cytotoxicity. In 5 another embodiment, a cell expressing LBP/p67 is exposed to a complex comprising a toxic agent and an LBP/p67 targeting agent, e.g., an LBP/p67 specific ligand or an LBP/p67 specific antibody, or a fragment thereof. In one embodiment, the toxic agent i conjugated to the LBP/p67 targeting agent. The LBP/p67 targeting agent directs the toxin to the cancer cell expressing LBP/p67 and the complex is internalized by the cell, 0 resulting in selective cytotoxicity of the cancer cell.
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申请公布号 |
WO2007022424(A3) |
申请公布日期 |
2007.07.12 |
申请号 |
WO2006US32351 |
申请日期 |
2006.08.17 |
申请人 |
PATRYS, PTY. LIMITED;ABRAMS, JOHN, S.;LONG, JOHN, J. |
发明人 |
ABRAMS, JOHN, S.;LONG, JOHN, J. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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