METHODS OF IDENTIFYING COMPOUNDS CAPABLE OF MODULATING T CELL IMMUNE RESPONSES INVOLVING SEMA4A PROTEIN

摘要

The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.