| 摘要 |
The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPARgamma) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount wherein in formula (I) W represents a COOH group or its bioisosters, or COO-C<SUB>1</SUB>-C<SUB>4</SUB>-alkyl group; Y represents NH or N-C<SUB>1</SUB>-C<SUB>10</SUB>-alkyl; Z represents NH, N-C<SUB>1</SUB>-C<SUB>10</SUB>-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C<SUB>1</SUB>-C<SUB>10</SUB>-alkyl, N-aryl, NSO<SUB>2</SUB>-C<SUB>1</SUB>-C<SUB>10</SUB>-alkyl, N-SO<SUB>2</SUB>-aryl, or N S0<SUB>2</SUB>-heteroaryl; R<SUB>1 </SUB>to R<SUB>6 </SUB>each independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.
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