| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for preparing levofloxacin and its new forms. SOLUTION: Levofloxacin is prepared by reacting (S)-(-)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid with N-methyl piperazine in a polar solvent or in a neat mixture to form levofloxacin. Further processing of the levofloxacin produces novel levofloxacin forms, including a hemihydrate and forms A, B, C, F, G and H. COPYRIGHT: (C)2007,JPO&INPIT
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