MULTIVALENT INDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

摘要

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase- related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds of the invention consist of linked indole derivatives having at ' least two bicyclic rings of formula FIG. 6C in which R₁R₇ are defined as in claim 1 and in which the fused five membered ring contains a nitrogen atom and the fused six membered ring optionally contains one or two nitrogen atoms. The two or more bicyclic rings of Figure 6c are joined by a multifunctional bridge moiety substituted by two or more linking groups L which are joined to the bicyclic ring.