4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES

摘要

A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR^x or CR^xR^y; if X=NR^x then n is 1 or 2 and if X=CR^xR^y then n is 1; R^x is selected from the group consisting of H, optionally substituted C^1-20 alkyl, C^5-20 aryl, C^3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R^y is selected from H, hydroxy, amino; or R^x and R^y may together form a spiro-C^3-7 cycloalkyl or heterocyclyl group; R^C1 and R^C2 are independently selected from the group consisting of hydrogen and C^1-4 alkyl, or when X is CR^xR^y, R^C1, R^C2, R^x and R^y, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R¹ is selected from H and halo; and Het is selected from: (i) formula (i), where Y¹ is selected from CH and N, Y² is selected from CH and N, Y³ is selected from CH, CF and N, where only one or two of Y¹, Y² and Y³ can be N; and (ii) formula (ii), where Q is O or S.