发明名称 |
NOVEL BONE METASTASIS MARKER PEPTIDE AND METHOD OF DIAGNOSING BONE METASTASIS BY USING THE SAME |
摘要 |
It is intended to provide: a peptide which shows an increase in the expression amount in the serum of a cancer patient with the passage of time before the onset of bone metastasis and after the onset of bone metastasis, is adsorbed by a weak cation exchanger at pH 6, and has an apparent molecular weight determined by mass spectrometry of about 5,800; a peptide fragment comprising the amino acid sequence corresponding to from 10- to 62-positions of the amino acid sequence of matured azurocidin; and a method of diagnosing bone metastasis in a cancer patient characterized by comprising detecting the expression of one of the above peptides in a biological sample originating in the cancer patient. According to this method, bone metastasis can be found and treated at the early stage.
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申请公布号 |
EP1803734(A1) |
申请公布日期 |
2007.07.04 |
申请号 |
EP20050790182 |
申请日期 |
2005.09.28 |
申请人 |
KURUME UNIVERSITY |
发明人 |
TSURU, MICHIYO;NAGATA, KENSEI;SATA, MICHIO |
分类号 |
C07K14/82;C12Q1/68;G01N33/574 |
主分类号 |
C07K14/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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