发明名称 |
TTP-related zinc finger domains and methods of use |
摘要 |
The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA molecule encoding TNF-alpha, and methods of inhibiting the degradation of an mRNA molecule encoding GM-CSF. Also provided are methods for identifying compounds that regulate the destruction of mRNA molecules containing AREs.
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申请公布号 |
US7238473(B1) |
申请公布日期 |
2007.07.03 |
申请号 |
US20000049586 |
申请日期 |
2000.08.14 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BLACKSHEAR PERRY J.;LAI WI S.;CARBALLO-JANE ESTER |
分类号 |
C12Q1/68;C07H21/04;C07K1/00;C12N9/00;G01N33/00;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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