发明名称 |
Amphiphilic heparin derivative formed by coupling a heparin with a bile acid |
摘要 |
The invention relates to an amphiphilic heparin derivative formed from at least one type of partially N-desulfated heparin and at least one type of bile acid comprising one or several bile acid molecules grafted on a heparin molecule by an amide bond formed between the terminal carboxylic acid function of a bile acid and a primary heparin amine function which is initially present in the heparin or resulting from the N-desulfation. The inventive derivative is characterized in that the number of grafted bile acid molecules per 100 heparin disaccharide units ranges from 15 to 80 approximately.
|
申请公布号 |
US2007141158(A1) |
申请公布日期 |
2007.06.21 |
申请号 |
US20040582989 |
申请日期 |
2004.12.17 |
申请人 |
ETHYPHARM |
发明人 |
HOARAU DIDIER;BOUSTTA MAHFOUD;BRAUD CHRISTIAN;VERT MICHEL |
分类号 |
A61K31/727;A61K9/10;A61K9/14;A61K47/36;C08B37/00;C08B37/10 |
主分类号 |
A61K31/727 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|