发明名称 Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation
摘要 The invention relates to the use of an inhibitor of formula (I), or a pharmaceutically acceptable salt thereof having an activity on protein kinases PKC alpha, PKC beta, PKC gamma, PKC epsilon, PKC theta, CDK-1, KDR, PKA, Flt-1, Flt-2, Flt-3 or Flt-4, or on a combination of the above enzymes, for the treatment and/or prevention of neurological and vascular disorders related to beta-amyloid generation and/or aggregation such as neurodegenerative diseases like Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, or cerebral hemorrhage with amyloidosis.
申请公布号 US2007142401(A1) 申请公布日期 2007.06.21
申请号 US20040576176 申请日期 2004.10.26
申请人 NOVARTIS AG 发明人 AUBERSON YVES;BILBE GRAEME;KUHN RAINER R.;VON MATT PETER;RUEGER HEINRICH;STAUFENBIEL MATTHIAS;WAGNER JURGEN;ZIMMERMANN KASPAR
分类号 A61K31/519;A61K31/00;A61K31/404;A61K31/4709;A61K31/496;A61K31/506;A61K31/517 主分类号 A61K31/519
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