| 摘要 |
Methods and compositions are disclosed for treating a patient suffering from a condition associated with a retinal and/or choroidal disease or disorder of the eye involving endothelial cell dysfunction, especially vascular endothelial cells of the eye, and especially before or in the absence of neovascularization. The therapeutic method involves administering a tetracycline, an analog of tetracycline, or a chemically modified tetracycline (CMT) to a patient suffering from such conditions. Also provided are compositions and methods for reducing breakdown of tight junctions in vascular endothelial cells; reducing IL-1 a concentrations; and inhibiting IL-1 a-mediated matrix metalloproteinase activity in endothelial cells of the eye and surrounding tissues.
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