Means and methods for influencing the stability of antibody producing cells

摘要

The invention provides methods for increasing the replicative life span and/or stability of an antibody producing cell, comprising
- providing said antibody producing cell with a compound capable of directly or indirectly enhancing BCL6 expression and/or culturing said antibody producing cell in the presence of a compound capable of directly or indirectly enhancing BCL6 expression; and
- directly or indirectly increasing the amount of Bcl-xL or another anti-apoptotic gene expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.