发明名称 |
Heterocyclic inhibitors of MEK and methods of use thereof |
摘要 |
Disclosed are compounds of the Formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, R<SUP>9 </SUP>and R<SUP>10</SUP>, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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申请公布号 |
US7230099(B2) |
申请公布日期 |
2007.06.12 |
申请号 |
US20040929295 |
申请日期 |
2004.08.30 |
申请人 |
ARRAY BIOPHARMA, INC. |
发明人 |
WALLACE, ELI;HURLEY, BRIAN;YANG, HONG WOON;LYSSIKATOS, JOSEPH;BLAKE, JIM;MARLOW, ALLISON |
分类号 |
C07D413/04;A61K31/42;C07D;C07D261/20;C07D401/04;C07D471/04;C07D471/06 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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