发明名称 |
Process for the preparation of substituted pyrrolidine derivatives and intermediates |
摘要 |
Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.
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申请公布号 |
US7230119(B2) |
申请公布日期 |
2007.06.12 |
申请号 |
US20050210691 |
申请日期 |
2005.08.25 |
申请人 |
BIOCRYST PHARMACEUTICALS, INC. |
发明人 |
CHAND POORAN;EL-KATTAN YAHYA;KOTIAN PRAVIN L. |
分类号 |
C07D207/06;C07D207/08;C07D207/09 |
主分类号 |
C07D207/06 |
代理机构 |
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代理人 |
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地址 |
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