Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration

摘要

This invention relates to pharmaceutical compositions for improving anesthesia recovery and preventing nausea and emesis and a method for improved injection site tolerance. In particular, the invention is directed to pharmaceutical compositions with an improved injection site toleration comprising an effective amount of a neurokinin receptor antagonist with a pharmaceutically acceptable cyclodextrin. The invention is also directed to pharmaceutical compositions of the compound of Formula (I), wherein R² is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl. The invention is also directed to pharmaceutical compositions of the compound of Formula Ia, and cyclodextrins and methods for improved injection site toleration thereof.