HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-COA DESATURASE.

摘要

Methods of treating an SCD-mediated disease or condition in a mammal, preferablya human, are disclosed, wherein the methods comprise administering to a mammalin need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W,R2, R3, R4, R5, R5a, R6,R6a, R7, R7a, R8 and R8a aredefined herein. Pharmaceutical compositions comprising the compounds of formula(I) are also disclosed.