发明名称 |
Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
摘要 |
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
|
申请公布号 |
US7227028(B2) |
申请公布日期 |
2007.06.05 |
申请号 |
US20040026491 |
申请日期 |
2004.12.30 |
申请人 |
XENOPORT, INC. |
发明人 |
GALLOP MARK A.;DAI XUEDONG;SCHEUERMAN RANDALL A.;RAILLARD STEPHEN P.;MANTHATI SURESH K.;YAO FENMEI;PHAN THU;LUDWIKOW MARIA;PENG GE;BHAT SEEMA |
分类号 |
C07D207/46;C07D207/404;C07D207/416 |
主分类号 |
C07D207/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|