摘要 |
This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HAS) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers. |
申请人 |
SIRNA THERAPEUTICS, INC.;BEIGELMAN, LEONID;MATULIC-ADAMIC, JASENKA;VARGEESE, CHANDRA;KARPEISKY, ALEXANDER;BLATT, LAWRENCE;SHAFFER, CHRISTOPHER |
发明人 |
BEIGELMAN, LEONID;MATULIC-ADAMIC, JASENKA;VARGEESE, CHANDRA;KARPEISKY, ALEXANDER;BLATT, LAWRENCE;SHAFFER, CHRISTOPHER |