发明名称 SPIROLACTAM BICYCLIC CGRP RECEPTOR ANTAGONISTS
摘要 Compounds of formula (I): (wherein variables A<SUP>1</SUP>, A<SUP>2</SUP>, A<SUP>3</SUP>, A<SUP>4</SUP>, A<SUP>5</SUP>, A<SUP>6</SUP>, A<SUP>7</SUP>, B, E<SUP>1</SUP>, E<SUP>2</SUP>, E<SUP>3</SUP>, E<SUP>4</SUP>, E<SUP>5</SUP>, G<SUP>1</SUP>, G<SUP>2</SUP>, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
申请公布号 WO2007061696(A2) 申请公布日期 2007.05.31
申请号 WO2006US44212 申请日期 2006.11.14
申请人 MERCK & CO., INC.;BELL, IAN, M.;SELNICK, HAROLD, G.;STUMP, CRAIG, A.;THEBERGE, CORY, R.;ZARTMAN, C., BLAIR 发明人 BELL, IAN, M.;SELNICK, HAROLD, G.;STUMP, CRAIG, A.;THEBERGE, CORY, R.;ZARTMAN, C., BLAIR
分类号 A61K31/55;C07D487/10 主分类号 A61K31/55
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