A method for improving the cytotoxic effect of Ecteinascidin-743 (ET-743) or an analog thereof on a tumor cell population in a patient the method including administering to the patient, sequentially or simultaneously, a therapeutically effective combination of a composition including ET-743 and an amount of a composition including a PARP-I inhibitor effective to increase the cytotoxic effect of ET-743 on the tumor cell population. Anti-tumor compositions containing a therapeutically effective amount of ET-743 and an amount of a PARP-I inhibitor effective to increase the tumor cytotoxicity of the ET-743 are also presented.
申请公布号
WO2007062413(A2)
申请公布日期
2007.05.31
申请号
WO2006US61254
申请日期
2006.11.27
申请人
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;SCOTTO, KATHLEEN, A.;MANDOLA, MICHAEL