| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain a substance useful for elucidating mechanism of pathogenesis of disease caused by relation to leukemia fusion protein having AML1, RUNX2 and RUNX3 being human transcription factors and a RUNT domain derived from AML1 such as leukemia-associated AML1-MTG8, AML1-MTG16, TEL-AML1, AML1-EVI1, AML1-EAP, AML1-MDS1, AML1-MDS1-EVI1, etc., and diagnosing and treating the diseases and a substance useful for research of an intracellular process such as transcription, etc. <P>SOLUTION: The RNA has an activity of binding to a RUN domain obtained by an SELEX method. The RNA aptamer is useful for functional analysis of a leukemia fusion protein having AML1, RUNX2, RUNX3 and a RUNX3 domain and diagnosing and treating diseases such as cancer, etc. <P>COPYRIGHT: (C)2007,JPO&INPIT |
