Effects of tissue transglutaminase on beta-amyloid-induced apoptosis

摘要

The present invention relates to a method of inhibiting beta-amyloid-induced death of neuronal cells in a subject by inhibiting human tissue transglutaminase in the subject under conditions effective to inhibit beta-amyloid-induced death of neuronal cells. Also disclosed are methods for identifying candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject by identifying compounds which are capable of binding to human tissue transglutaminase as candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject. The present invention also relates to compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject, as well as methods for designing such compounds.