CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870

摘要

NMB 1870 is a protein in Neisseria meningitidis. Three families of NMB 1870 are known. To increase the ability of a NMB 1870 protein to elicit antibodies that are cross-reactive between the families, NMB 1870 is engineered. Sequences can be substituted from one NMB 1870 family into the corresponding position in another family. Proteins of NMB 1870 sequences from different families can be joined to each other.