CONSTRAINED HIV ENVELOPE-BASED IMMUNOGEN THAT SIMULTANEOUSLY PRESENTS RECEPTOR AND CORECEPTOR BINDING SITES
摘要
<p>The present invention relates to a soluble binding complex comprising a soluble gp120 trimer, in which only two gp120 protomers have CD4 binding sites occupied by interconnecting CD4 mimetic moieties, thereby allowing for the exposure of CD4-induced epitopes on the mimetic-bound protomers and an unoccupied CD4 binding site on the third gp120 protomer.</p>
申请公布号
WO2007005934(A3)
申请公布日期
2007.05.31
申请号
WO2006US26136
申请日期
2006.07.06
申请人
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE;DEVICO, ANTHONY, L.;LEWIS, GEORGE;WANG, LAI-XI