18F-LABELED DAA ANALOGUES AND METHODS OF LABELING THESE ANALOGUES AS POSITRON EMISSION TOMOGRAPHY (PET) TRACERS FOR IMAGING PERIPHERAL BENZODIAZEPINE RECEPTORS

摘要

Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with <SUP>18</SUP>F using one-step syntheses are provided. Analogues labeled with the <SUP>18</SUP>F using the one-step synthesis method are also provided. Additionally, the purification of the Br, I, C1, TsO, MsO, or R<SUB>f</SUB>SO<SUB>3</SUB> precursors in the compound of formula (II) by solid phase extraction is provided as is the precursor compounds of formula (II). Kit and method of use claims for comprising an effective amount of an <SUP>18</SUP>F labeled compound, and pharmaceutically acceptable salts and solvates thereof are also provided.