Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them

摘要

Disclosed is a compound of general formula (I) wherein: R0 is either H or linear or branched (C1-C2) alkyl R1-R12 independently represent H, halogen, perhaloalkyl, amino, substituted or unsubstituted groups such as linear or branched alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, heterocyclylalkyloxy, cyl, acyloxy, acylamino, monoalkylamino, dialkylamino, arylamino, diarylamino, aralkylamino, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkoxyalkyl, alkylthio, amioncarbonylamino, dialkylaminocarbonylamino, carboxylic acid and its derivatives; R13 and R14 independently represent H, or substituted or unsubsituted groups such as linear or branched alkyl, cycloalkyl, cycloalkenyl, bicycloalkyl, bicycloalkenyl, aryl, aralkyl; or R13 and R14 along with the N atom may form a 3, 4, 5, 6 or 7 membered heterocyclic ring wherein the ring may be further substituted and may have either one, two or three double bonds or "additional heteroatoms" as define above; and "n" is an integer ranging from 1-6, the carbon chains which 'n' represents may be either linear or branched.