| 摘要 |
Diastereoselective and enantioselective synthetic routes for the preparation of compounds of formula (I): or derivatives thereof, wherein: R is C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>1-6</SUB>alkoxy, hydroxy, halo, C<SUB>1-6</SUB>alkenyl, C<SUB>1-6</SUB>alkynyl, amino, C<SUB>1-6</SUB>alkylamino, di(C<SUB>1-6</SUB>alkyl)amino, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxyC<SUB>1-6</SUB>alkyl, arylC<SUB>1-6</SUB>alkoxy, heteroarylC<SUB>1-6</SUB>alkoxy, aminoC<SUB>1-6</SUB>alkyl, (C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, arylC<SUB>1-6</SUB>alkylamino, heteroarylC<SUB>1-6</SUB>alkyamino; R<SUP>1 </SUP>is hydrogen or R; R<SUP>2 </SUP>is hydroxy, C<SUB>1-6</SUB>alkoxy, amino, C<SUB>1-6</SUB>alkylamino, di(C<SUB>1-6</SUB>alkyl)amino; R<SUP>3 </SUP>and R<SUP>4 </SUP>are each independently selected from the list consisting of perhaloC<SUB>1-6</SUB>alkyl, hydrogen, halo, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, hydroxy, amino, C<SUB>1-6</SUB>alkylamino, di(C<SUB>1-6</SUB>alkyl)amino, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxyC<SUB>1-6</SUB>alkyl, aminoC<SUB>1-6</SUB>alkyl,(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, aryl, and COX wherein X may be hydroxy, C<SUB>1-6 </SUB>alkoxy, C<SUB>1-6</SUB>alkyl, amino, C<SUB>1-6</SUB>alkylamino, or di(C<SUB>1-6</SUB>alkyl)amino; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more times by halo.
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