发明名称 |
N-acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and/or tumor |
摘要 |
An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galbeta1-4Glc or Galbeta1-4GlcNAc-group via a beta-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal beta1-4Glc or Gal beta1-4GlcNAc-group via a beta-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
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申请公布号 |
US7223580(B2) |
申请公布日期 |
2007.05.29 |
申请号 |
US20050507421 |
申请日期 |
2005.03.11 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY |
发明人 |
NARIMATSU HISASHI;INABA NIRO;TOGAYACHI AKIRA |
分类号 |
C12N9/10;C07H21/04;C12N1/15;C12N1/19;C12N1/21;C12N5/16;C12N15/12;C12N15/70;C12P19/04;C12P21/06;C12Q1/68 |
主分类号 |
C12N9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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