| 摘要 |
The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provide s useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283ml per ml of water at standard conditions . The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is belo w 80 daltons. The second component is present in a proportion of between 59-99 .5 % by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxi de or mixtures thereof. Gas mixtures described are found to be very effective a s ultrasound contrast media. The invention also comprises a method of making t he ultrasound contrast medium, the contrast agent and the ultrasound agent kit.
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