发明名称 |
NEW 3'-TERMINAL SEQUENCE OF HEPATITIS C VIRUS GENOME AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new RNA sequence at the 3'-terminal sequence of an HCV (hepatitis C virus) genome RNA. <P>SOLUTION: A 3' sequence having a specific base sequence of the HCV (hepatitis virus) genome RNA, a complement thereof and use thereof for nucleic acid-based diagnosis and new anti-HCV therapies are provided. The sequence element which is conserved among the HCV genotypes is essential for viral replication and required for construction of full-length HCV cDNA clones yielding an infectious RNA, a progeny virus or replication-competent HCV replicons. The functional clones are useful tools for evaluation of the therapeutic approaches and as substances for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV. <P>COPYRIGHT: (C)2007,JPO&INPIT |
申请公布号 |
JP2007125028(A) |
申请公布日期 |
2007.05.24 |
申请号 |
JP20060333874 |
申请日期 |
2006.12.11 |
申请人 |
WASHINGTON UNIV |
发明人 |
RICE CHARLES III;KOLYKHALOV ALEXANDER A |
分类号 |
C12N15/09;G01N33/50;A61K31/00;A61K38/00;A61K38/21;A61K39/00;A61K45/00;A61K48/00;A61P1/00;A61P1/16;A61P31/00;A61P31/12;A61P31/20;A61P35/00;C07K14/18;C12N5/08;C12N5/10;C12N7/00;C12Q1/70;G01N33/566;G01N33/576 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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