| 摘要 |
Disclosed herein is a method for the production of disulfide compounds of the formula (I) PAC-SA-SB-R* (I) wherein PAC-SA is a residue of a pharmaceu tically active drug a metabolite thereof or a pharmaceutically acceptable sa lt thereof that is covalently bonded via the sulfur atom, SA of a reduced su lfhydryl, sulfinyl, sulfonyl or sulfonamide group to the sulfur atom SB of a n oxidised sulfhydryl group of a pharmacologically acceptable sulfhydryl com pound in the absence of an acid. Preferably the pharmaceutically active drug is a proton pump inhibitor and the sulfhydryl compound is N-acetyl cysteine . The disulfide compounds according to the invention can be prepared either in vitro or in vivo and are stable in the acidic conditions of the stomach. Pharmaceutical compositions containing compounds of the formula (I) and a me thod for the treatment or prophylaxis of gastrointestinal disorders using co mpounds of the formula (I) are also described.
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